Did you know that Indiana University chemists created the first fluoride toothpaste? Dr. Harry Day, Dr. Joseph Muhler, and Dr. William Nebergall developed the invention that changed the modern dental industry.

Before the invention of fluoride toothpaste, ingredients in the product during the 1800s included soap and chalk, and even before that contained harsh ingredients like crushed bones and oyster shells. Problems from poor oral hygiene resulted in dentures made of wood or ivory. Since these elements did little to protect oral health, scientists were needed to develop an effective solution. 

Oxford University conducted early research that showed fluoride in water would prevent tooth decay. In 1950, Procter & Gamble funded research for Indiana University scientists to create a new toothpaste formula. After years of studies, in 1955, Procter & Gamble’s Crest debuted the first toothpaste containing fluoride. 

Fluoride toothpaste prevented tooth decay and established an entire category around tooth preservation. Companies like Colgate Palmolive and Proctor-Gamble have driven consistent growth in this category for years. The dental fluoride treatment industry is worth $11.2 billion dollars today and is dominated by toothpaste, resulting from an innovation partnership between University and industry.

Partnering with universities is a viable way to innovate and drive growth to your organization. Where to begin is often the most difficult part. FirstIgnite will help your organization identify and partner with the specific universities, laboratories, and experts that you need in order to create the next category-defining innovation, like fluoride toothpaste.

Related resouces

FirstIgnite delivers AI-powered prospecting, agentic outreach, and partnership data management—giving impact-driven organizations everything they need to grow meaningful partnerships.

Connecting Industry & Academia

CMU and Fujitsu Launch Physical AI Research Center

April 27, 2026
xx
MIN READ
Connecting Industry & Academia

Cyberonix and Korea University Partner to Accelerate AI Innovation and Industry Collaboration

March 31, 2026
xx
MIN READ
Connecting Industry & Academia

UW and Microsoft Are Redefining AI Education and Workforce Readiness

February 26, 2026
xx
MIN READ